Download Angiotensin II receptor antagonists : current perspectives by Mancia Giuseppe PDF

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By Mancia Giuseppe

Considering that angiotensin II is without doubt one of the such a lot effective vasoconstrictors and a tremendous stimulus for the secretion of aldosterone from the adrenal gland, the improvement of of angiotensin II inhibitors is a crucial step in regulating blood strain. This category of drug is well-tolerated by way of pateints and those medications have the additional virtue over ACE inhibitors in that they're no longer linked to cough. simply because so much medications will be given as soon as day-by-day and, like ACEIs, they've got an invaluable additive hypotensive influence together with diuretics, they seem to be a welcome healing device within the therapy of high blood pressure. This moment variation builds at the luck of the 1st and brings to the reader all of the most recent advancements, scientific trial info, and the contributors's own views while treating sufferers with angiotensin II receptors antagonists.

  • offers chapters through recognized individuals within the fields of either high blood pressure and middle failure, specifically with reference to pharmacological interventions
  • covers the recent position of AIIR in neuroprotection
  • builds upon the strengths of the 1st edition
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    Repression of c-fos and c-jun gene expression is not part of AT2 receptor coupled signal transduction. J Mol Med 1998; 76:202–7. 22. Gallinat S, Busche S, Schutze S, Kronke M, Unger T. AT2 receptor stimulation induces generation of ceramides in PC12W cells. FEBS Lett 1999; 443:75–9. 23. Meffert S, Stoll M, Steckelings UM, Bottari SP, Unger T. The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells. Mol Cell Endocrinol 1996; 122:59–67. 24. Laflamme L, Gasparo M, Gallo JM, Payet MD, Gallo-Payet N.

    13. Seibold S, Rudroff C, Weber M et al. 3-22. FASEB J 2003; 17:1180–2. 14. Kaschina E, Unger T. Angiotensin AT1/AT2 receptors: regulation, signalling and function. Blood Press 2003; 12:70–88. 556 7/3/06 4:06 pm Page 43 References 43 15. Widdop RE, Jones ES, Hannan RE, Gaspari TA. Angiotensin AT2 receptors: cardiovascular hope or hype? Br J Pharmacol 2003; 140:809–24. 16. Stroth U, Blume A, Mielke K, Unger T. Angiotensin AT(2) receptor stimulates ERK1 and ERK2 in quiescent but inhibits ERK in NGF-stimulated PC12W cells.

    556 7/3/06 4:06 pm Page 31 Stimulation of AT2 receptors: role in the effect of angiotensin II receptor antagonists 3 Heiko Funke-Kaiser, Ulrike Muscha Steckelings, and Thomas Unger Introduction This chapter will focus on the hypothesis that angiotensin AT1 receptor blockers (ARBs) act not only by blocking the deleterious effects of angiotensin II type 1 receptor (AT1R) activation but also by indirectly activating the angiotensin II type 2 receptor (AT2R). To discuss this mechanism, knowledge about the signal transduction cascade and the cellular and biological effect of the AT2R is crucial.

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