Download Angiotensin II receptor antagonists : current perspectives by Mancia Giuseppe PDF
By Mancia Giuseppe
Considering that angiotensin II is without doubt one of the such a lot effective vasoconstrictors and a tremendous stimulus for the secretion of aldosterone from the adrenal gland, the improvement of of angiotensin II inhibitors is a crucial step in regulating blood strain. This category of drug is well-tolerated by way of pateints and those medications have the additional virtue over ACE inhibitors in that they're no longer linked to cough. simply because so much medications will be given as soon as day-by-day and, like ACEIs, they've got an invaluable additive hypotensive influence together with diuretics, they seem to be a welcome healing device within the therapy of high blood pressure. This moment variation builds at the luck of the 1st and brings to the reader all of the most recent advancements, scientific trial info, and the contributors's own views while treating sufferers with angiotensin II receptors antagonists.
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Extra info for Angiotensin II receptor antagonists : current perspectives
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556 7/3/06 4:06 pm Page 31 Stimulation of AT2 receptors: role in the effect of angiotensin II receptor antagonists 3 Heiko Funke-Kaiser, Ulrike Muscha Steckelings, and Thomas Unger Introduction This chapter will focus on the hypothesis that angiotensin AT1 receptor blockers (ARBs) act not only by blocking the deleterious effects of angiotensin II type 1 receptor (AT1R) activation but also by indirectly activating the angiotensin II type 2 receptor (AT2R). To discuss this mechanism, knowledge about the signal transduction cascade and the cellular and biological effect of the AT2R is crucial.