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By John Robin Baker
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2013. Elsevier. St. Louis. 608–638. 37. Valli VE, Myint MS, Barthel A, et al. Classification of canine malignant lymphomas according to the World Health Organization criteria. Vet Path. 2011; 48:198–211. 38. Valli VE, Vernau W, de Lorimier P, et al. Canine indolent nodular lymphoma. Vet Path. 2006; 43:241–256. 39. Burnett RC, Vernau W, Modiano JF, et al. Diagnosis of Canine Lymphoid Neoplasia Using Clonal Rearrangements of Antigen Receptor Genes. Vet Path. 2003; 40:32–41. 40. Vail DM, Pinkerton ME, Young, KE.
679–688. 24. Kruse MA, Holmes ES, Balko JA, et al. Evaluation of Clinical and Histopathologic Prognostic Factors for Survival in Canine Osteosarcoma of the Extracranial Flat and Irregular Bones. Vet Path 2013; 50:704–708. 25. Aeffner F, Weeren R, Morrison S, et al. Synovial Osteochondromatosis with Malignant Transformation to Chondrosarcoma in a Dog. Vet Path 2012; 49:1036–1039. 26. Mehl ML, Withrow SJ, Seguin B, et al. Spontaneous remission of osteosarcoma in four dogs. JAVMA 2001; 219:614–617.
Complete excision of this type of lesion is often curative. 65 shows the splenic biopsy from an adult cat with a diffusely enlarged spleen. This is an indication for immediate diagnostic workup. The complete blood count (CBC) can be searched for circulating mast cells, and evaluation of abdominal fluid for mast cells is also an appropriate procedure prior to surgery. Mast cells are not normally seen in these fluids, and the finding of more than rare mast cells in the CBC or abdominal fluid is supportive of splenic mast cell tumor when there is splenomegaly.