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Download Annals of Oncology: Official Journal of the European Society by Brian L. Samuels, John E. Ultmann (auth.), John E. Ultmann, PDF

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By Brian L. Samuels, John E. Ultmann (auth.), John E. Ultmann, Brian L. Samuels (eds.)

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Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen. Am J Pathol 1990;136: 1215-1222. 18. Pinkus GS, Said JW. Hodgkin's disease, lymphocyte predominance type, nodular - further evidence for a B cell derivation. AmJ Pathol1988; 133:211-217. 19. Dallenbach FE, Stein H. Expression of T-Cell-Receptor j3Chain in Reed-Sternberg Cells. Lancet 1989; ii: 828-830. 20. Stein H, Gerdes J, Schwab U, Lemke H, Diehl V, Mason DY, Bartels H, Ziegler A. Evidence for the detection of the normal counterpart of Hodgkin's and Sternberg-Reed cells.

5). Reassessment by bone marrow biopsy of the patient with previously documented bone marrow involvement now showed the marrow to be free of lymphoma. No consistent alteration in mean LV bone marrow T 2 was seen following treatment, although reduction or OL-----~--------------~--- Fig. 4. Pre- and post-treatment mean lumbar vertebral marrow T 1 of patients studied serially. ). n_•_____P_os_:_-tLre_a_tm_e_nt Fig. 5. Pre- and post-treatment percent T 1 variation of patients studied serially. ). normalisation of T 2 variation was seen in three of the four patients studied serially.

The second antibody is a polyclonal anti-CD3 antibody effective on paraffin sections [16]. The third important antibody is L26, which was shown by Mason et al. to be directed against the B cell-specific CD20 molecule [17]. The staining results obtained with these antibodies on a large series of HD cases are summarized in Table 4. These data show that in lymphocyte-predominant HD, the B-cell antigen CD20 is expressed at a high density, and there is no expression of the TCR 13 chain [18, 19]. This varies from results seen in other types of HD, which showed a heterogenous pattern of reactivity [19].

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