Cardiovascular

Download Antithrombotic Therapy in Prevention of Ischemic Stroke by Richard C Becker, Frederick A Spencer PDF

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By Richard C Becker, Frederick A Spencer

Stroke is the commonest explanation for grownup mortality within the usa. Antithrombotic brokers shape the mainstay of stroke prevention. Aspirin produces a modest aid within the possibility of moment stroke and temporary ischemic assault (TIA, mini-stroke) and is broadly advised for preliminary remedy. The thienopyridines (Ticlid) and clopodogrel (Plavix) are choices for secondary prevention in sufferers who don't reply to or can't take aspirin. they're not more powerful than aspirin and feature been linked to thrombotic thrombocytopenic purpura. the combo of aspirin and extended-release dipyridamole (Aggrenox) has a number of mechanisms of motion and an additive impression on decreasing stroke hazard in comparison with both agent on my own. A 2-fold raise in threat aid and favorable security profile recommend that the combo can function first-line prophylaxis opposed to a moment stroke. This quantity, as a part of the Oxford American Pocket Note sequence, presents the clinician wtih updated info at the guidance, and healing strategies in recurrent stroke/TIA prevention. beneficial beneficial properties contain remedy algorithms, illustrations, medicine tables, charts and figures to let either the professional and the first supplier to make sure the easiest techniques to their sufferers for you to hinder the reocurrence of stroke/TIA.

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Jantzen HM, Vincent D, et al. Identification of the platelet ADP receptor targeted by anti-thrombotic drugs. Nature 2001;409:202–7. 42 ANTITHROMBOTIC THERAPY 30. Bennett CL, Connors JM, Carwile JM, et al. Thrombotic thrombocytopenia purpura associated with clopidogrel. N Engl J Med 2000;342:1773–7. 31. ; TRITONTIMI 38 Investigators. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007; 357(20):2001–15. 32. CAPRIE Steering Committee. A randomized, blinded trial of clopidogrel versus aspirin in patients at risk for ischemic events (CAPRIE).

Jantzen HM, Vincent D, et al. Identification of the platelet ADP receptor targeted by anti-thrombotic drugs. Nature 2001;409:202–7. 42 ANTITHROMBOTIC THERAPY 30. Bennett CL, Connors JM, Carwile JM, et al. Thrombotic thrombocytopenia purpura associated with clopidogrel. N Engl J Med 2000;342:1773–7. 31. ; TRITONTIMI 38 Investigators. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007; 357(20):2001–15. 32. CAPRIE Steering Committee. A randomized, blinded trial of clopidogrel versus aspirin in patients at risk for ischemic events (CAPRIE).

Near-field amplification of antithrombotic effects of dipyridamole through vessel wall cells. Neurology 2001;57(5 Suppl 2):S20–3. 43. Diener HC, Cunha L, Forbes C, et al. European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 1996; 143:1–13. 44. ESPRIT Study Group, Halkes PH, van Gijn J, Kappelle LJ, et al. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial.

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